Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition

Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation.

Acquisition and performance of instrumental actions are assumed to require both action-outcome and stimulus-response (S-R) habit processes. Over the course of extended training, control over instrumental performance shifts from goal-directed action-outcome associations to S-R associations that progressively gain domination over behavior. Lesions of the lateral part of the dorsal striatum disrup...

Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.

The dopamine (DA) D2 receptor (D2R)-expressing medium spiny neurons (D2-MSNs) in the striatum project to and inhibit the GABAergic neurons in the globus pallidus (GP), forming an important link in the indirect pathway of the basal ganglia movement control circuit. These striatopallidal axon terminals express presynaptic D2Rs that inhibit GABA release and thus regulate basal ganglion function. H...

Controls for lesions of the nigrostriatal dopamine system.

A Neural Network Model of the Primate Saccadic System

........................................................................................................... i Résumé ............................................................................................................. ii Acknowledgements .......................................................................................... iii List of Figures ..........................................

Time Course of Recovery of Extracellular Dopamine Damage to the Nigrostriatal Dopamine System following Partial

Partial damage to the nigrostriatal dopamine (DA) system can produce severe behavioral deficits, from which animals gradually recover. Although the compensatory neuroadaptations that contribute to recovery of function have received considerable attention, the exact role of presynaptic versus postsynaptic contributions remains unclear. For example, it has been suggested that presynaptic adaptati...